Raloxifene:
A New Medication to Fight Osteoporosis

Women now have another medication to build bone and reduce the risk of fracture associated with osteoporosis. Raloxifene (ruh-LOCKS-uh-feen) hydrochloride, a medication used to prevent osteoporosis, now can be used to treat the condition. During menopause, dense bones lose mass faster than they can replace it. As they become thin and porous, bones can fracture easily. To slow this process, doctors often prescribe medications, such as alendronate (Fosamax), estrogen, or calcitonin (Calcimar), that help slow the rate of bone loss and help rebuild bone. Raloxifene joins this small group of bone-building medications. Recently, researchers showed that raloxifene helps build bone in the spine and hip and reduces the risk of vertebral (spine bones) fractures.¹ In addition, the medication is associated with a lower incidence of breast cancer and has been shown to lower "bad" cholesterol levels.^1,2 Although, the medication does not relieve menopausal symptoms, it provides an alternative for women who cannot or will not take estrogen, alendronate, or calcitonin due to certain side effects, risk factors, or other problems.

1. Ettinger B, Black DM, Mitlak BH, et al. Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene. JAMA 1999;282:637-645.
2. Khovidhunkit W, Shoback DM. Clinical effects of raloxifene hydrochloride in women. Ann Internal Med 1999;130:431-439.